Two questions:

Are there any issues running dslrdashbord through the router using a Mac? Or is it better to run the camera through a USB cable?

And, if using the router, are their issues installing the firmware with a Mac?

Thanks,

Peter

You can flash the OpenWrt from any PC running Windows, Linux or OSX. You only need a browser and a network connection to the router (best to have a wired one).
As of running qDD on OSX I can only test with my 'hacintosh' running Mavericks on my laptop and there it works.
I also tested in a virtual box running Mountain Lion and also worked.