I'm curious about where people do their sharpening in your LRTimelapse workflow.  I follow the standard Lightroom workflow of correcting keyframes.  I typically do not change the sharpening there and do it at the end when I assemble my video in Premiere Pro.  There, I add a sharpening Effect.  I was wondering if it makes any difference to add sharpening to the keyframe images in Lightroom.  Any thoughts?

I usually don't add sharpening to the keyframes, since its mostly not necessary if you use good lenses. Sharpening in Lightroom additionally makes the export process even longer. I'd suggest using the sharpening option in the LRTimelapse render dialog. It will apply the sharpening to the video after resizing to the output size.