Hello! Sorry if this has been asked before. I already have my Lightroom keyframes set up and have a large chunk of frames removed. If I want to see what it looks like with some new frames added would it be wise to throw the removed images back into the main folder and reload?

I'm not sure, if totally understand what you are trying to do.
I assume you are talking about removing and readding image files from/to a timelapse sequence.
Best would do to do this in LRTimelapse - there are options in the right click menu for "Remove Images", "Move Images" etc. which you could use - in that case, you don't need to reload in LRT at all.
Only after you have your final set of images, you should go to Lightroom, and right click on the folder with the final images and do "Synchronize".